Picking up twelve years after the conclusion of the last movie, John and his thunder-buddy Ted are neighbors, both with families of their own and dead-end jobs. Follow these two lovable stoners as they enable each other's bad ideas about marriage, parenting and the challenges of adult life.

The Horton and Brady broods endure the romantic trials of life in Salem, a Midwestern hamlet filled with evil geniuses, star-crossed lovers and a rich family history.